How is cis-3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride (CAS: 1408075-16-0) typically synthesized?

cis-3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride is typically synthesized by a multistep process starting from 3-cyclobutanecarboxylic acid. The key steps include the conversion of the acid to the corresponding amine, followed by bromination to introduce the trifluoromethyl group. Finally, the chloride is added to form the hydrochloride salt. This process involves mild conditions and can achieve yields of up to 85%.