Compound Q&A
How is ent-Lurasidone Hydrochloride (CAS: 1448443-35-3) typically synthesized?
Answer
Ent-Lurasidone Hydrochloride is synthesized through a multi-step process involving the protection of a hydroxyl group, subsequent electrophilic aromatic substitution, and deprotection. The reaction typically requires catalysts such as palladium and bases like potassium phosphate. The overall yield is around 50-60%, with high selectivity towards the desired product.
About
CAS No
1448443-35-3
English Name
ent-Lurasidone Hydrochloride
Molecular Formula
C28H36N4O2S
Molecular Weight
492.676045417786 g/mol
SMILES
S1C2C=CC=CC=2C(=N1)N1CCN(CC1)C[C@H]1CCCC[C@@H]1CN1C([C@H]2[C@@H](C1=O)[C@@H]1CC[C@H]2C1)=O
InChIKey
PQXKDMSYBGKCJA-YBEUTXPYSA-N
Last Updated: 2026-03-28 19:11
