Compound Q&A
How is 1-(3-Bromo-5-(trifluoromethyl)pyridin-2-yl)ethanone (CAS: 1048384-87-7) typically synthesized?
Answer
1-(3-Bromo-5-(trifluoromethyl)pyridin-2-yl)ethanone is typically synthesized using electrophilic aromatic substitution. The reaction involves bromination of 5-(trifluoromethyl)pyridine followed by nucleophilic substitution with ethanoyl chloride. Common catalysts include triphenylphosphine and 4-dimethylaminopyridine, yielding a product with high selectivity and good to moderate yield.
About
CAS No
1048384-87-7
English Name
1-(3-Bromo-5-(trifluoromethyl)pyridin-2-yl)ethanone
Molecular Formula
C8H5BrF3NO
Molecular Weight
268.03 g/mol
SMILES
CC(=O)C1=C(C=C(C=N1)C(F)(F)F)Br
InChIKey
OJRLRMIXUHYYMO-UHFFFAOYSA-N
Last Updated: 2026-03-22 14:59
