How is 7-Fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine] (CAS: 1283090-73-2) typically synthesized?

7-Fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine] is typically synthesized through a multistep reaction involving the condensation of 2-amino-3-fluoropyridine with 4-piperidone. The reaction proceeds under basic conditions, and the yield is around 70-80%. The use of a catalyst such as sodium hydroxide can improve the selectivity and yield of the target compound.