Compound Q&A

How is 2-Chloro-1,1-difluoroethane (CAS: 338-65-8) typically synthesized?

Answer

2-Chloro-1,1-difluoroethane
2-Chloro-1,1-difluoroethane (CAS: 338-65-8) is typically synthesized by the chlorination of 1,1-difluoroethane in the presence of a Lewis acid catalyst, such as aluminum chloride. This process involves the electrophilic aromatic substitution of the difluoroethane with chlorine. The yield is around 70-80%, and the product is purified by distillation.

About

CAS No 338-65-8
English Name 2-Chloro-1,1-difluoroethane
Molecular Formula C2H3ClF2
Molecular Weight 100.5 g/mol
SMILES C(C(F)F)Cl
InChIKey ATEBGNALLCMSGS-UHFFFAOYSA-N
Last Updated: 2026-03-16 17:23

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