Compound Q&A
How is (4R,12aS)-N-(2,6-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (CAS: 2244161-72-4) typically synthesized?
Answer
![(4R,12aS)-N-(2,6-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide](https://static.chemtradehub.com/structs/224/2244161-72-4-c823.webp "(4R,12aS)-N-(2,6-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide")
The compound is synthesized via a multi-step process involving protection of the amine, introduction of the difluorobenzyl group, and subsequent ring closure. Commonly, the synthesis involves using reagents like DMF and catalysts such as HATU for amide formation. The yield is typically around 70%, with high selectivity towards the desired product.
About
CAS No
2244161-72-4
English Name
(4R,12aS)-N-(2,6-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Molecular Formula
C20H19F2N3O5
Molecular Weight
419.38 g/mol
SMILES
C[C@@H]1CCO[C@H]2CN3C=C(C(=O)NCC4C(F)=CC=CC=4F)C(=O)C(O)=C3C(=O)N21
InChIKey
HINIWTFBDFXRFH-BMIGLBTASA-N
Last Updated: 2026-03-16 13:10
![(4R,12aS)-N-(2,6-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide — Shenzhen Moho BioTechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cea6402b2de6e8e95a497f/67cea6402b2de6e8e95a497f-logo.webp){kind=logo}