Compound Q&A

How is 6-Methoxy-1-naphthonitrile (CAS: 77029-01-7) typically synthesized?

Answer

6-Methoxy-1-naphthonitrile
6-Methoxy-1-naphthonitrile can be synthesized via the nitrilation of 1-methoxy-2-naphthol using sodium nitrite and sulfuric acid as the nitrating agent. The reaction is carried out under acidic conditions, and the product is obtained with a good yield. This method provides high selectivity and good regiochemical control.

About

CAS No 77029-01-7
English Name 6-Methoxy-1-naphthonitrile
Molecular Formula C12H9NO
Molecular Weight 172.23 g/mol
SMILES COC1=CC2=C(C=C1)C(=CC=C2)C#N
InChIKey PGQFNNJLLVRLLW-UHFFFAOYSA-N
Last Updated: 2026-03-16 13:10

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