Compound Q&A
How is benzyl (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-ylcarbamate (CAS: 877384-16-2) typically synthesized?
Answer
Benzyl (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-ylcarbamate is typically synthesized via a multi-step process involving the coupling of benzyl bromide with (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-amine. The reaction is catalyzed by a palladium-based catalyst under microwave irradiation. The yield is around 85%, and the selectivity is high, with minimal side products.
About
CAS No
877384-16-2
English Name
benzyl (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-ylcarbamate
Molecular Formula
C19H17F6NO3
Molecular Weight
421.33 g/mol
SMILES
CC(C(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O)NC(=O)OCC2=CC=CC=C2
InChIKey
AWBAPOAGBOTVOQ-ZBEGNZNMSA-N
Last Updated: 2026-03-11 12:33
