Compound Q&A
How is 4-(Hydroxymethyl)pyridine-2-carboxylic acid (CAS: 923169-37-3) typically synthesized?
Answer
4-(Hydroxymethyl)pyridine-2-carboxylic acid can be synthesized via the condensation of 2-hydroxypyridine with acetyl chloride in the presence of a catalytic amount of p-toluenesulfonic acid. The reaction yields a mixture, which can be purified by column chromatography. Alternatively, it can be synthesized from 4-hydroxypyridine-2-carboxylic acid using hydrogenation to introduce the hydroxymethyl group.
About
CAS No
923169-37-3
English Name
4-(Hydroxymethyl)pyridine-2-carboxylic acid
Molecular Formula
C7H7NO3
Molecular Weight
153.137 g/mol
SMILES
C1=CN=C(C=C1CO)C(=O)O
InChIKey
QMLYYPGJXCVEHA-UHFFFAOYSA-N
Last Updated: 2026-03-10 19:33
