Compound Q&A
How is 4-(3-Methylphenyl)piperidine hydrochloride (CAS: 80120-03-2) typically synthesized?
Answer
4-(3-Methylphenyl)piperidine hydrochloride is synthesized by treating 4-(3-methylphenyl)piperidine with hydrochloric acid. The reaction typically involves an esterification step followed by acid treatment to form the hydrochloride salt. Common solvents used include methanol, and the yield is usually around 85-90%. Catalysts such as sulfuric acid are often used to improve the reaction rate and selectivity.
About
CAS No
80120-03-2
English Name
4-(3-Methylphenyl)piperidine hydrochloride (1:1)
Molecular Formula
C12H18ClN
Molecular Weight
211.74 g/mol
SMILES
CC1=CC(=CC=C1)C2CCNCC2.Cl
InChIKey
ZVKQARCPEZNELE-UHFFFAOYSA-N
Last Updated: 2026-03-10 19:33
