Compound Q&A
How is (3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid (CAS: 854898-48-9) typically synthesized?
Answer
![(3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid](https://static.chemtradehub.com/structs/854/854898-48-9-e5ac.webp "(3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid")
The synthesis of (3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid typically involves multistep reactions, including aromatic substitution, alkylation, and condensation. The key steps include the formation of a 6-aminobenzo[h]quinazoline intermediate, followed by amidation and esterification. This process often requires the use of catalysts and organic solvents, with high selectivity and yield achievable under optimized conditions.
About
CAS No
854898-48-9
English Name
(3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid
Molecular Formula
C22H28FN3O6S
Molecular Weight
481.55 g/mol
SMILES
CC(C)c1c2c(nc(n1)N(C)S(=O)(=O)C)-c3ccc(cc3[C@@H](C2)[C@H](C[C@H](CC(=O)O)O)O)F
InChIKey
FHIVIRAXRANEIW-QBIMZIAESA-N
Last Updated: 2026-03-10 14:55
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![(3R,5S)-5-{(6R)-8-Fluoro-4-isopropyl-2-[methyl(methylsulfonyl)amino]-5,6-dihydrobenzo[h]quinazolin-6-yl}-3,5-dihydroxypentanoic acid — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}