Compound Q&A

How is N-{3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl}-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylcarboxamide (CAS: 170230-39-4) typically synthesized?

Answer

N-{3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl}-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylcarboxamide
This compound is typically synthesized via a multistep process involving the formation of an oxadiazole ring and coupling with a biphenyl derivative. Commonly, the synthesis involves the use of catalytic amounts of palladium in the presence of a ligand, followed by coupling with an appropriate amino-containing compound. The overall yield is around 70-75%.

About

English Name N-{3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl}-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylcarboxamide
Molecular Formula C28H30N4O4
Molecular Weight 486.57200000000034 g/mol
SMILES CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)OCCN(C)C
InChIKey JRNUKVFYILMMLX-UHFFFAOYSA-N
Last Updated: 2026-03-10 14:55

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