Compound Q&A

How is 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS: 1006340-71-1) typically synthesized?

Answer

1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid
1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid can be synthesized through the condensation of trifluoroethylamine and 1H-pyrazole-5-carboxylic acid anhydride. This reaction is typically carried out in the presence of a catalytic amount of a Lewis acid such as aluminum trichloride to enhance the reactivity and yield. The process is exothermic and requires careful temperature control.

About

English Name 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid
Molecular Formula C6H5F3N2O2
Molecular Weight 194.11 g/mol
SMILES OC(=O)c1ccnn1CC(F)(F)F
InChIKey AYCDWZAEGMKZNB-UHFFFAOYSA-N
Last Updated: 2026-03-08 04:51

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