Compound Q&A
How is (5alpha,6beta)-17-(2-Phenylethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride (CAS: 5013-01-4) typically synthesized?
Answer
(5alpha,6beta)-17-(2-Phenylethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride is typically synthesized via a multistep process involving epoxidation of a morphinan derivative followed by coupling with a phenylethyl chloride. The synthesis often requires the use of catalysts such as titanium tetrachloride and is performed under anhydrous conditions. Yield is generally around 70-80%, with good selectivity for the desired product.
About
CAS No
5013-01-4
English Name
(5alpha,6beta)-17-(2-Phenylethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride (1:1)
Molecular Formula
C24H28ClNO4
Molecular Weight
429.94 g/mol
SMILES
c1ccc(cc1)CCN2CC[C@]34c5c6ccc(c5O[C@H]3[C@@H](CC[C@]4([C@H]2C6)O)O)O.Cl
InChIKey
SQDHJNHUMXSVCJ-OFNSMXRKSA-N
Last Updated: 2026-03-08 04:51