Compound Q&A

How is 1-(3,5-Dimethoxyphenyl)cyclobutanecarbonitrile (CAS: 339094-25-6) typically synthesized?

Answer

1-(3,5-Dimethoxyphenyl)cyclobutanecarbonitrile
1-(3,5-Dimethoxyphenyl)cyclobutanecarbonitrile can be synthesized via a multistep process involving the reaction of 3,5-dimethoxybenzaldehyde with cyclobutanecarbonitrile. The synthesis typically uses a Lewis acid catalyst such as aluminum chloride to promote the condensation reaction. The yield of the product can be up to 85% with good selectivity towards the desired diastereomer.

About

English Name 1-(3,5-Dimethoxyphenyl)cyclobutanecarbonitrile
Molecular Formula C13H15NO2
Molecular Weight 206.28499999999994 g/mol
SMILES COc1cc(OC)cc(c1)C2(CCC2)C#N
InChIKey VHUDXFOGTXMRMR-UHFFFAOYSA-N
Last Updated: 2026-03-08 04:51

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