Compound Q&A
How is 2-Methyl-6-(trifluoromethyl)quinoline (CAS: 66023-21-0) typically synthesized?
Answer
2-Methyl-6-(trifluoromethyl)quinoline is typically synthesized via the trifluoromethylation of 2-methylquinoline using triflic anhydride as the reagent. This reaction is often catalyzed by Lewis acids, such as aluminum trichloride, and proceeds under mild conditions. The yield is generally good, and the product is isolated by recrystallization from an appropriate solvent.
About
CAS No
66023-21-0
English Name
2-Methyl-6-(trifluoromethyl)quinoline
Molecular Formula
C11H8F3N
Molecular Weight
211.18599999999998 g/mol
SMILES
CC1=NC2=C(C=C1)C=C(C=C2)C(F)(F)F
InChIKey
VHSCBEQRKQRFEK-UHFFFAOYSA-N
Last Updated: 2026-03-07 19:49
