Compound Q&A
How is 3-(3-Chlorophenyl)-2-propynoic acid (CAS: 7396-28-3) typically synthesized?
Answer
3-(3-Chlorophenyl)-2-propynoic acid is typically synthesized by reacting 3-chlorophenyllithium with acetylene followed by acid workup. The reaction is carried out in tetrahydrofuran (THF) at low temperature, and the yield is generally high, around 70-80%. Palladium catalysis can be used to improve selectivity and yield.
About
CAS No
7396-28-3
English Name
3-(3-Chlorophenyl)-2-propynoic acid
Molecular Formula
C9H5ClO2
Molecular Weight
60.05 g/mol
SMILES
C1=CC(=CC(=C1)Cl)C#CC(=O)O
InChIKey
FRTZPNZKFMZQDR-UHFFFAOYSA-N
Last Updated: 2026-03-07 19:49
