Compound Q&A
How is 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (CAS: 1338365-54-0) typically synthesized?
Answer
![5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile](https://static.chemtradehub.com/structs/133/1338365-54-0-811a.webp "5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile")
5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile is synthesized through a multi-step process involving the condensation of indole with a benzoyl chloride derivative, followed by alkylation and amination reactions. Commonly used solvents include dichloromethane, acetonitrile, and pyridine. The reaction is conducted under mild conditions, and the product is isolated by recrystallization or filtration, with yields typically ranging from 70-85%.
About
CAS No
1338365-54-0
English Name
5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
Molecular Formula
C22H25N3O2
Molecular Weight
363.45 g/mol
SMILES
N#Cc1cc(CC(N)C)cc2c1N(CCCOC(=O)c1ccccc1)CC2
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Last Updated: 2026-03-05 12:33
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