How is (3-Bromo-2-thienyl)boronic acid (CAS: 162607-26-3) typically synthesized?

The synthesis of (3-Bromo-2-thienyl)boronic acid typically involves the bromination of 2-thiophenecarboxylic acid followed by the formation of the boronic acid ester. Common methods include the use of N-bromosuccinimide (NBS) in the presence of a radical initiator, followed by a catalytic boronation step using a palladium catalyst. High selectivity and yield can be achieved under optimized conditions.