How is 4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine (CAS: 5734-68-9) typically synthesized?

4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine is typically synthesized by the nucleophilic substitution of 2-chloropyrimidine with dimethylamine. Common methods involve using dimethylamine in acetic acid solution at room temperature. The reaction is selective and yields up to 90% of the desired product. The use of a catalyst such as sodium acetate can enhance the reaction selectivity and yield.