Compound Q&A
How is 4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol (CAS: 72948-89-1) typically synthesized?
Answer
![4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol](https://static.chemtradehub.com/structs/729/72948-89-1-8cc3.webp "4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol")
4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol can be synthesized via a condensation reaction between 1,2-butanediol and bicyclo[2.2.2]oct-2-ene. Commonly, this reaction is catalyzed by sodium hydride under anhydrous conditions. The reaction is typically carried out at room temperature, and the yield can reach up to 75%. The desired product can be isolated by column chromatography.
About
CAS No
72948-89-1
English Name
4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol
Molecular Formula
C9H16O2
Molecular Weight
156.22 g/mol
SMILES
OCC12CCC(O)(CC1)CC2
InChIKey
SLPTVDBWTSIOKW-UHFFFAOYSA-N
Last Updated: 2026-03-01 17:11
![4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol — Nanjing YashiTech Shareholding Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce363a57537e5c8069b51c/67ce363a57537e5c8069b51c-logo.webp){kind=logo}
![4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol — JiangSuAiKangShengWuYiYaoYanFa Co Ltd](https://static.chemtradehub.com/suppliers/67cec9452b2de6e8e95a52fa/67cec9452b2de6e8e95a52fa-logo.webp){kind=logo}
![4-(Hydroxymethyl)bicyclo[2.2.2]octan-1-ol — Beijing Bailingwei Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cde31e57537e5c8069aebf/67cde31e57537e5c8069aebf-logo.webp){kind=logo}