Compound Q&A

How is 2,6-Dichloro-4-(trifluoromethyl)benzonitrile (CAS: 157021-61-9) typically synthesized?

Answer

2,6-Dichloro-4-(trifluoromethyl)benzonitrile
2,6-Dichloro-4-(trifluoromethyl)benzonitrile is typically synthesized via the reaction of 2,6-dichlorotoluene with trifluoroacetonitrile in the presence of a suitable base such as potassium carbonate. The reaction is carried out under anhydrous conditions, and the yield is generally good, around 70-80%. This synthesis involves the nucleophilic substitution of the toluene ring with trifluoromethyl and nitrile groups.

About

English Name 2,6-Dichloro-4-(trifluoromethyl)benzonitrile
Molecular Formula C8H2Cl2F3N
Molecular Weight 240.01 g/mol
SMILES C1=C(C=C(C(=C1Cl)C#N)Cl)C(F)(F)F
InChIKey NCXSSFQXQAOREM-UHFFFAOYSA-N
Last Updated: 2026-03-01 17:11

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