Compound Q&A
How is 4-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-3-(difluoromethoxy)benzamide (CAS: 162401-43-6) typically synthesized?
Answer
4-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-3-(difluoromethoxy)benzamide is synthesized via a multi-step process involving the condensation of 3,5-dichloro-4-pyridinylamine with a difluoromethoxy substituted benzoyl chloride, followed by alkylation with cyclopropylmethyl bromide. The reaction is catalyzed by a combination of a Lewis acid and a base, with high selectivity and good yield.
About
CAS No
162401-43-6
English Name
4-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-3-(difluoromethoxy)benzamide
Molecular Formula
C17H14Cl2F2N2O3
Molecular Weight
403.21 g/mol
SMILES
Clc3c(NC(=O)c2ccc(OCC1CC1)c(OC(F)F)c2)c(Cl)cnc3
InChIKey
VXNCCFGMEHFNBA-UHFFFAOYSA-N
Last Updated: 2026-01-04 19:14
