Compound Q&A

How is 3-(4-Bromophenyl)-5-methyl-1H-pyrazole (CAS: 145353-53-3) typically synthesized?

Answer

3-(4-Bromophenyl)-5-methyl-1H-pyrazole
3-(4-Bromophenyl)-5-methyl-1H-pyrazole can be synthesized through a multistep process involving bromination of an aromatic ring followed by a condensation reaction. Commonly, bromobenzene is brominated using N-bromosuccinimide (NBS) or N-iodosuccinimide (NIS) in the presence of a radical initiator. Subsequently, the bromobenzene derivative is treated with a pyrazole ring precursor, such as 1,3-dimethylpyrazole, in an appropriate solvent like dichloromethane or toluene under reflux conditions.

About

English Name 3-(4-Bromophenyl)-5-methyl-1H-pyrazole
Molecular Formula C10H9BrN2
Molecular Weight 237.1 g/mol
SMILES CC1=CC(=NN1)C2=CC=C(C=C2)Br
InChIKey WANDSSMDLLHHCJ-UHFFFAOYSA-N
Last Updated: 2026-01-04 19:14

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