Compound Q&A
How is 8-Methyl-8-azabicyclo[3.2.1]octan-2-one (CAS: 78477-91-5) typically synthesized?
Answer
![8-Methyl-8-azabicyclo[3.2.1]octan-2-one](https://static.chemtradehub.com/structs/784/78477-91-5-08af.webp "8-Methyl-8-azabicyclo[3.2.1]octan-2-one")
8-Methyl-8-azabicyclo[3.2.1]octan-2-one (CAS: 78477-91-5) is typically synthesized via a multi-step process involving the cycloaddition of 1,3-diketone with a nitrogen-containing compound such as morpholine. The reaction is catalyzed by a base and proceeds with excellent regioselectivity. The overall yield is around 70-80%, and the product can be isolated by recrystallization.
About
CAS No
78477-91-5
English Name
8-Methyl-8-azabicyclo[3.2.1]octan-2-one
Molecular Formula
C8H13NO
Molecular Weight
139.2 g/mol
SMILES
O=C1CCC2N(C1CC2)C
InChIKey
VIZAOHGVLPCBMA-UHFFFAOYSA-N
Last Updated: 2026-01-01 20:06
![8-Methyl-8-azabicyclo[3.2.1]octan-2-one — JiangSuAiKangShengWuYiYaoYanFa Co Ltd](https://static.chemtradehub.com/suppliers/67cec9452b2de6e8e95a52fa/67cec9452b2de6e8e95a52fa-logo.webp){kind=logo}
![8-Methyl-8-azabicyclo[3.2.1]octan-2-one — Matrix Scientific](https://static.chemtradehub.com/suppliers/67cec8282b2de6e8e95a50be/67cec8282b2de6e8e95a50be-logo.webp){kind=logo}
![8-Methyl-8-azabicyclo[3.2.1]octan-2-one — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}