Compound Q&A
How is ethyl 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxylate (dihydrochloride) (CAS: 163521-09-3) typically synthesized?
Answer
Ethyl 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxylate (dihydrochloride) is synthesized via a multi-step process involving coupling reactions and final hydrochloridation. The synthesis involves the use of a palladium catalyst and requires high purity reagents. The yield is typically 70-80%, and the product is isolated by recrystallization from ethanol.
About
CAS No
163521-09-3
English Name
ethyl 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxylate (dihydrochloride)
Molecular Formula
C28H32Cl2N4O3
Molecular Weight
459.59 g/mol
SMILES
CCOC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)C#N.Cl.Cl
InChIKey
IUIWYNHWHWFSDU-UHFFFAOYSA-N
Last Updated: 2026-01-01 20:06
