Compound Q&A
How is 6-Chloro-1H-indole-3-carbonitrile (CAS: 194490-17-0) typically synthesized?
Answer
6-Chloro-1H-indole-3-carbonitrile is typically synthesized via the cyanation of 6-chloro-1H-indole using sodium cyanide in an organic solvent like dimethylformamide (DMF). This process involves the use of a catalyst such as potassium carbonate to enhance the reaction yield. The reaction is usually carried out under nitrogen atmosphere to prevent reaction with oxygen. The yield is typically around 70-80%.
About
CAS No
194490-17-0
English Name
6-Chloro-1H-indole-3-carbonitrile
Molecular Formula
C9H5ClN2
Molecular Weight
165.62 g/mol
SMILES
C1=CC2=C(C=C1Cl)NC=C2C#N
InChIKey
HLDCXNREKOGGFC-UHFFFAOYSA-N
Last Updated: 2026-01-01 20:06
