Compound Q&A
How is [2-(1H-Pyrazol-1-yl)phenyl]methanol (CAS: 741717-59-9) typically synthesized?
Answer
![[2-(1H-Pyrazol-1-yl)phenyl]methanol](https://static.chemtradehub.com/structs/741/741717-59-9-50dd.webp "[2-(1H-Pyrazol-1-yl)phenyl]methanol")
[2-(1H-Pyrazol-1-yl)phenyl]methanol (CAS: 741717-59-9) can be synthesized via a multistep process starting from 2-chlorophenol and pyrazole. The reaction involves the coupling of 2-chlorophenol with pyrazole under basic conditions, followed by reduction of the resulting chlorophenyl group to a hydroxyl group. Common catalysts include palladium(II) acetate with triphenylphosphine, and the overall yield is around 70-80%.
About
CAS No
741717-59-9
English Name
[2-(1H-Pyrazol-1-yl)phenyl]methanol
Molecular Formula
C10H10N2O
Molecular Weight
174.2 g/mol
SMILES
C1=CC=C(C(=C1)CO)N2C=CC=N2
InChIKey
HDACOBLOISVBLA-UHFFFAOYSA-N
Last Updated: 2026-01-01 06:12
![[2-(1H-Pyrazol-1-yl)phenyl]methanol — ShenZhenAiTaHuaXue Co Ltd](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fa/67ced0fb2b2de6e8e95a67fa-logo.webp){kind=logo}
![[2-(1H-Pyrazol-1-yl)phenyl]methanol — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}