Compound Q&A
How is L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine (CAS: 72122-62-4) typically synthesized?
Answer
L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine is synthesized via solid-phase peptide synthesis (SPPS). Commonly, Fmoc (fluorenylmethyloxycarbonyl) or t-Boc (tert-butyloxycarbonyl) protection strategies are used. The synthesis involves coupling of the respective amino acid building blocks using suitable coupling reagents such as HATU (O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) and HOBt (1-hydroxybenzotriazole). The final step involves cleavage from the solid support and deprotection to yield the desired peptide.
About
CAS No
72122-62-4
English Name
L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine
Molecular Formula
C41H55N7O9
Molecular Weight
789.93 g/mol
SMILES
CCC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)CNC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)N
InChIKey
RKYJTDSQXOMDAD-JKXTZXEVSA-N
Last Updated: 2026-01-01 06:12
