Compound Q&A

How is 1-Benzhydryl-3-fluoroazetidine (CAS: 617718-45-3) typically synthesized?

Answer

1-Benzhydryl-3-fluoroazetidine
1-Benzhydryl-3-fluoroazetidine is typically synthesized through a multi-step process involving the formation of a benzhydryl amine followed by alkylation and fluorination. The synthesis involves the use of a Lewis acid catalyst, such as aluminum chloride, and involves protecting group strategies to control the reactivity of the intermediates. The overall yield is moderate, and purification is achieved through recrystallization and chromatography.

About

English Name 1-Benzhydryl-3-fluoroazetidine
Molecular Formula C16H16FN
Molecular Weight 241.31 g/mol
SMILES C1C(CN1C(C2=CC=CC=C2)C3=CC=CC=C3)F
InChIKey ZYKWABRWFBVPIJ-UHFFFAOYSA-N
Last Updated: 2026-01-01 01:49

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