Compound Q&A
How is (2S,3S)-3-{[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid (CAS: 1629869-44-8) typically synthesized?
Answer
![(2S,3S)-3-{[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid](https://static.chemtradehub.com/structs/162/1629869-44-8-8554.webp "(2S,3S)-3-{[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid")
This compound can be synthesized via a multi-step process involving the condensation of 5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid with a pyrimidine derivative. The reaction is typically carried out in the presence of a suitable base and solvent. The yield is moderate, and the reaction is selective for the desired product.
About
CAS No
1629869-44-8
English Name
(2S,3S)-3-{[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid
Molecular Formula
C20H19F2N5O2
Molecular Weight
399.4 g/mol
SMILES
OC(=O)[C@@H]1[C@@H](Nc2nc(ncc2F)c3c[nH]c4ncc(F)cc34)C5CCC1CC5
InChIKey
JGPXDNKSIXAZEQ-SBBZOCNPSA-N
Last Updated: 2025-12-31 21:15
![(2S,3S)-3-{[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid — ShangHaiMaiRuiErShengHua Technology Co Ltd](https://static.chemtradehub.com/suppliers/67ced3b52b2de6e8e95a6e52/67ced3b52b2de6e8e95a6e52-logo.webp){kind=logo}