Compound Q&A

How is 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate (CAS: 871700-32-2) typically synthesized?

Answer

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
This compound is typically synthesized via a multi-step process involving the protection of the cyclopropyl group, followed by the installation of the fluoro-iodophenyl moiety using a palladium-catalyzed coupling reaction. Additional steps include the introduction of the dimethyl group and the formation of the pyrimidine ring. The yield is generally moderate (50-70%), and the process requires careful control of reaction conditions to ensure high selectivity.

About

English Name 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
Molecular Formula C25H21FIN3O6S
Molecular Weight 637.4269999999999 g/mol
SMILES O=S(C1=CC=C(C)C=C1)(OC(C(C(N2C3CC3)=O)=C4N(C5=CC=C(I)C=C5F)C2=O)=C(C)C(N4C)=O)=O
InChIKey RCCOZJPSLZNDFV-UHFFFAOYSA-N
Last Updated: 2025-12-31 06:49

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