Compound Q&A

How is 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate methanesulfonate (CAS: 246852-12-0) typically synthesized?

Answer

3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate methanesulfonate (1:1)
The compound is synthesized via a multi-step process that includes amidation, esterification, and methylation reactions. Commonly, a chiral auxiliary is used to achieve stereochemical control, and the reaction is typically carried out under mild conditions to ensure high selectivity and yield. Catalysts such as sodium hydride or potassium carbonate are employed to facilitate the reactions.

About

English Name 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate methanesulfonate (1:1)
Molecular Formula C21H29ClN2O8S
Molecular Weight 504.99 g/mol
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.CS(=O)(=O)O
InChIKey MUVFCHUBATVFPP-UHFFFAOYSA-N
Last Updated: 2025-12-31 06:49

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