Compound Q&A
How is (R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol (CAS: 139290-65-6) typically synthesized?
Answer
![(R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol](https://static.chemtradehub.com/structs/139/139290-65-6-beaa.webp "(R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol")
This compound is typically synthesized via coupling reactions of the appropriate piperidine and 2-(4-fluorophenyl)ethyl derivatives. The synthesis involves the use of a palladium catalyst, such as Pd(PPh3)2Cl2, in the presence of a base like triphenylphosphine. The yield can be around 70-80% with high selectivity to the desired (R)-configuration.
About
CAS No
139290-65-6
English Name
(R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol
Molecular Formula
C22H28FNO3
Molecular Weight
373.47 g/mol
SMILES
COC1=CC=CC(=C1OC)C(C2CCN(CC2)CCC3=CC=C(C=C3)F)O
InChIKey
HXTGXYRHXAGCFP-OAQYLSRUSA-N
Last Updated: 2025-12-29 01:16
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