Compound Q&A
How is 1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde (CAS: 169036-71-9) typically synthesized?
Answer
1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde can be synthesized via the Knoevenagel condensation of 4-fluorophenylhydrazine with pyrrole, followed by oxidation. Commonly, this condensation is catalyzed by acid, and the final oxidation step is typically performed using chromic acid or periodate. The yield and selectivity can be improved by optimizing reaction conditions, such as temperature and catalyst concentration.
About
CAS No
169036-71-9
English Name
1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde
Molecular Formula
C11H8FNO
Molecular Weight
189.19 g/mol
SMILES
C1=CN(C(=C1)C=O)C2=CC=C(C=C2)F
InChIKey
JDANDWLVCIKGCA-UHFFFAOYSA-N
Last Updated: 2025-12-28 19:55
