Compound Q&A

How is (1E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-ol (CAS: 76714-88-0) typically synthesized?

Answer

(1E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-ol
(1E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-ol is synthesized via a multi-step process involving the coupling of 2,4-dichlorophenyl isocyanide with methyl 3-aminopentanoate followed by the reaction with 1,2,4-triazole. The reaction typically occurs in the presence of a base like sodium hydride and is optimized for high yield and selectivity. The final product is isolated by column chromatography.

About

CAS No 76714-88-0
English Name (1E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-ol
Molecular Formula C15H17Cl2N3O
Molecular Weight 326.23 g/mol
SMILES CC(C)(C)C(C(=CC1=C(C=C(C=C1)Cl)Cl)N2C=NC=N2)O
InChIKey FBOUIAKEJMZPQG-AWNIVKPZSA-N
Last Updated: 2025-12-28 19:55

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