Compound Q&A
How is 5-[(1-{[(4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy]carbonyl}-4-piperidinyl)amino]pentanoic acid (CAS: 181467-56-1) typically synthesized?
Answer
![5-[(1-{[(4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy]carbonyl}-4-piperidinyl)amino]pentanoic acid](https://static.chemtradehub.com/structs/181/181467-56-1-e40f.webp "5-[(1-{[(4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy]carbonyl}-4-piperidinyl)amino]pentanoic acid")
The compound is synthesized via a multi-step process involving the condensation of a piperidine derivative with an indolizinoquinoline derivative. The reaction is catalyzed by a suitable acid acceptor and proceeds through a Michael addition followed by saponification. The overall yield is moderate, around 50-60%, and the reaction is highly selective.
About
CAS No
181467-56-1
English Name
5-[(1-{[(4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy]carbonyl}-4-piperidinyl)amino]pentanoic acid
Molecular Formula
C33H38N4O8
Molecular Weight
618.69 g/mol
SMILES
CCc1c2cc(ccc2nc-3c1Cn4c3cc5c(c4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)NCCCCC(=O)O
InChIKey
BSVVZICJFYZDJJ-UHFFFAOYSA-N
Last Updated: 2025-12-28 14:56
![5-[(1-{[(4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy]carbonyl}-4-piperidinyl)amino]pentanoic acid — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}