Compound Q&A
How is 2-Ethynyl-5-(trifluoromethyl)pyridine (CAS: 379670-42-5) typically synthesized?
Answer
2-Ethynyl-5-(trifluoromethyl)pyridine can be synthesized via the acetylene coupling reaction of 3-chloro-5-(trifluoromethyl)pyridine with acetylene in the presence of a palladium catalyst. The reaction is carried out in an inert atmosphere to avoid decomposition. The yield is typically around 70-80%, and the reaction mixture is then purified by recrystallization.
About
CAS No
379670-42-5
English Name
2-Ethynyl-5-(trifluoromethyl)pyridine
Molecular Formula
C8H4F3N
Molecular Weight
171.12 g/mol
SMILES
C#CC1=NC=C(C=C1)C(F)(F)F
InChIKey
PISOZFXTSONWKH-UHFFFAOYSA-N
Last Updated: 2025-12-28 14:56
