Compound Q&A

How is 4-(4-Fluorophenoxy)benzonitrile (CAS: 215589-24-5) typically synthesized?

Answer

4-(4-Fluorophenoxy)benzonitrile
4-(4-Fluorophenoxy)benzonitrile can be synthesized via a two-step process. First, 4-fluorophenol is treated with sodium nitrite and hydrochloric acid to form 4-fluorophenyl nitrile. Then, this nitrile is reacted with benzylic bromide or tosyl chloride to form the desired benzonitrile derivative. The reaction conditions and catalysts can influence the yield and selectivity, with the use of appropriate reagents and solvents being crucial for a successful synthesis.

About

English Name 4-(4-Fluorophenoxy)benzonitrile
Molecular Formula C13H8FNO
Molecular Weight 213.21 g/mol
SMILES C1=CC(=CC=C1C#N)OC2=CC=C(C=C2)F
InChIKey NXVPHQNXBDDVCT-UHFFFAOYSA-N
Last Updated: 2025-12-28 06:21

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