Compound Q&A
How is N-(4-Chlorophenyl)-3-oxobutanamide (CAS: 140-49-8) typically synthesized?
Answer
N-(4-Chlorophenyl)-3-oxobutanamide (CAS: 140-49-8) can be synthesized by reacting 4-chlorophenylacetic acid with acetic anhydride in the presence of a catalytic amount of a Lewis acid such as aluminum trichloride. The reaction is typically conducted in a non-polar organic solvent like toluene under reflux conditions. The yield is usually around 80-85%, and the product can be isolated by recrystallization from ethanol.
About
CAS No
140-49-8
English Name
N-(4-Chlorophenyl)-3-oxobutanamide
Molecular Formula
C10H10ClNO2
Molecular Weight
211.64799999999997 g/mol
SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)CCl
InChIKey
JMRJWEJJUKUBEA-UHFFFAOYSA-N
Last Updated: 2025-12-26 02:37
