Compound Q&A
How is 4-chloro-6-fluoro-1H-indole (CAS: 885520-79-6) typically synthesized?
Answer
4-Chloro-6-fluoro-1H-indole is commonly synthesized through the condensation of 6-fluoronicotinic acid with chloroacetophenone. This reaction is typically catalyzed by a base such as sodium hydroxide, and the yield is usually around 70-80%. The selectivity for the desired product is high, and the reaction is carried out under mild conditions, making it a viable method for industrial production.
About
CAS No
885520-79-6
English Name
4-chloro-6-fluoro-1H-indole
Molecular Formula
C8H5ClFN
Molecular Weight
169.59 g/mol
SMILES
C1=CNC2=C1C(=CC(=C2)F)Cl
InChIKey
ZIXPMUOPYURNOC-UHFFFAOYSA-N
Last Updated: 2025-12-25 08:48
