Compound Q&A

How is Methyl 3-(hydroxymethyl)cyclobutanecarboxylate (CAS: 89941-55-9) typically synthesized?

Answer

Methyl 3-(hydroxymethyl)cyclobutanecarboxylate
Methyl 3-(hydroxymethyl)cyclobutanecarboxylate (CAS: 89941-55-9) is typically synthesized through the addition of methanol to 3-chlorocyclobutanone in the presence of a base such as potassium hydroxide. The reaction is conducted in a polar aprotic solvent like dimethylformamide (DMF) at room temperature, yielding a mixture of diastereomers with high selectivity. The product is then isolated and purified by recrystallization.

About

CAS No 89941-55-9
English Name Methyl 3-(hydroxymethyl)cyclobutanecarboxylate
Molecular Formula C7H12O3
Molecular Weight 144.17 g/mol
SMILES COC(=O)C1CC(C1)CO
InChIKey LQUXXSRNBCFGDV-UHFFFAOYSA-N
Last Updated: 2025-12-25 08:48

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