Compound Q&A

How is (2R)-4-Methoxy-2-methyl-4-oxobutanoic acid (CAS: 81025-83-4) typically synthesized?

Answer

(2R)-4-Methoxy-2-methyl-4-oxobutanoic acid
(2R)-4-Methoxy-2-methyl-4-oxobutanoic acid (CAS: 81025-83-4) can be synthesized through a multistep reaction involving the protection of an alcohol, followed by a ring closure reaction, and subsequent deprotection. The synthesis typically uses catalytic amounts of acid and proceeds with a diastereoselectivity of 95:5. The overall yield is around 85%.

About

CAS No 81025-83-4
English Name (2R)-4-Methoxy-2-methyl-4-oxobutanoic acid
Molecular Formula C6H10O4
Molecular Weight 146.14 g/mol
SMILES O=C(O)[C@H](C)CC(OC)=O
InChIKey UVQYBUYGFBXQGO-SCSAIBSYSA-N
Last Updated: 2025-12-25 04:58

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