Compound Q&A
How is 1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine (CAS: 84030-19-3) typically synthesized?
Answer
![1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine](https://static.chemtradehub.com/structs/840/84030-19-3-80fd.webp "1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine")
1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine is synthesized using solid-phase peptide synthesis (SPPS) techniques. The synthesis involves coupling the 9-fluorenylmethoxycarbonyl (Fmoc) protected histidine with the benzyl ester, followed by removal of the Fmoc group. Commonly used conditions include the use of coupling agents like HATU and DIPEA in an N,N-dimethylformamide (DMF) solvent. The overall yield is typically around 70-85%, depending on the purity of starting materials and reaction conditions.
About
CAS No
84030-19-3
English Name
1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine
Molecular Formula
C28H25N3O4
Molecular Weight
467.53 g/mol
SMILES
c1ccc(cc1)Cn2cc(nc2)C[C@@H](C(=O)O)NC(=O)OCC3c4ccccc4-c5c3cccc5
InChIKey
AZBCBZPTQNYCPF-SANMLTNESA-N
Last Updated: 2025-12-25 04:58
![1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine — ShangHaiMaiRuiErShengHua Technology Co Ltd](https://static.chemtradehub.com/suppliers/67ced3b52b2de6e8e95a6e52/67ced3b52b2de6e8e95a6e52-logo.webp){kind=logo}
![1-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine — ShangHaiYiJiShengWuKeJiYouXianGongSiXiaoShouBu](https://static.chemtradehub.com/suppliers/67cecfe92b2de6e8e95a656d/67cecfe92b2de6e8e95a656d-logo.webp){kind=logo}