How is Methyl 6-octadecenoate (CAS: 14620-36-1) typically synthesized?

Methyl 6-octadecenoate is usually synthesized via esterification of 6-octadecenoic acid with methanol in the presence of a strong acid catalyst, such as sulfuric acid. The reaction is typically conducted at temperatures around 100°C. Optimal conditions include a molar ratio of 1:2 (acid:methanol) and a reaction time of 4-6 hours. Good yield is achieved with high selectivity towards the desired ester product.