Compound Q&A
How is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid (CAS: 641571-13-3) typically synthesized?
Answer
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid can be synthesized through a multi-step process involving the condensation of 4-methylimidazole with 5-bromo-3-(trifluoromethyl)benzoic acid, followed by an esterification step with methanol using a suitable base like potassium carbonate. The overall yield is around 70-80%, and the synthesis requires careful control of conditions to ensure high purity and selectivity.
About
CAS No
641571-13-3
English Name
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21 g/mol
SMILES
CC1=CN(C=N1)C2=CC(=CC(=C2)C(F)(F)F)C(=O)O
InChIKey
ZQOCDOFDUXPNGM-UHFFFAOYSA-N
Last Updated: 2025-11-08 00:00
