Compound Q&A
How is Tesamorelin (CAS: 218949-48-5) typically synthesized?
Answer
Tesamorelin (CAS: 218949-48-5) is synthesized using solid-phase peptide synthesis (SPPS) techniques. The synthesis involves coupling protected amino acids to a solid support, followed by deprotection and coupling of the next amino acid. The final step includes cyclization and purification using HPLC. Commonly used reagents include Boc-protected amino acids and Fmoc chemistry. The overall yield is around 50-70%, depending on the scale of synthesis.
About
CAS No
218949-48-5
English Name
Tesamorelin (usan)
Molecular Formula
C221H366N72O67S
Molecular Weight
5135.78 g/mol
SMILES
S(C)CC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)=O)=O)CCCNC(=N)N)=O)CCC(=O)O)=O)CCC(N)=O)=O)=O)=O)CCC(=O)O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(=O)O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(=N)N)NC([C@H](C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(=N)N)NC([C@H](CC1C=CC(=CC=1)O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)O)NC([C@H](CC1C=CC=CC=1)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(=O)O)NC([C@H](C)NC([C@H](CC1C=CC(=CC=1)O)NC(C/C=C/CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChIKey
QBEPNUQJQWDYKU-BMGKTWPMSA-N
Last Updated: 2025-11-07 19:01
