Compound Q&A

How is 3-(1,1,2,2-Tetrafluoroethoxy)aniline (CAS: 831-75-4) typically synthesized?

Answer

3-(1,1,2,2-Tetrafluoroethoxy)aniline
3-(1,1,2,2-Tetrafluoroethoxy)aniline (CAS: 831-75-4) is commonly synthesized through the reaction of aniline with 1,1,2,2-tetrafluoroethanol in the presence of a suitable catalyst, such as a strong base like sodium hydride. The process involves dehydrating the alcohol to form the corresponding anilide, followed by hydrolysis to introduce the tetrafluoroethoxy group. The overall yield of the reaction is typically around 70-80%.

About

CAS No 831-75-4
English Name 3-(1,1,2,2-Tetrafluoroethoxy)aniline
Molecular Formula C8H7F4NO
Molecular Weight 209.14 g/mol
SMILES Nc1cccc(OC(F)(F)C(F)F)c1
InChIKey MWDPEBMCVXNSPL-UHFFFAOYSA-N
Last Updated: 2025-11-07 19:01

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