Compound Q&A
How is 4-Chloro-5-fluoro-1H-indole-2,3-dione (CAS: 84378-94-9) typically synthesized?
Answer
4-Chloro-5-fluoro-1H-indole-2,3-dione (CAS: 84378-94-9) is typically synthesized via a multi-step process involving indole ring formation and subsequent chlorination and fluorination. Commonly, indole is protected at the C3 position, followed by chlorination and subsequent fluorination steps. The process involves the use of Lewis acids and halogenating agents, with yields ranging from 50% to 70%.
About
CAS No
84378-94-9
English Name
4-Chloro-5-fluoro-1H-indole-2,3-dione
Molecular Formula
C8H3ClFNO2
Molecular Weight
199.57 g/mol
SMILES
O=C1NC2=C(C(Cl)=C(F)C=C2)C1=O
InChIKey
SWUGYKGLXFMLEN-UHFFFAOYSA-N
Last Updated: 2025-11-07 12:11
