Compound Q&A
How is (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one (CAS: 128-62-1) typically synthesized?
Answer
![(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one](https://static.chemtradehub.com/structs/128/128-62-1-289d.webp "(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one")
The compound is typically synthesized via a multistep sequence involving a condensation reaction followed by a ring closure. Key catalysts include Lewis acids like AlCl3, and the overall yield is around 70%. The synthesis involves careful control of temperature and reaction time to achieve the desired stereochemistry and selectivity.
About
CAS No
128-62-1
English Name
(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
Molecular Formula
C22H23NO7
Molecular Weight
413.43 g/mol
SMILES
CN1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
InChIKey
AKNNEGZIBPJZJG-MSOLQXFVSA-N
Last Updated: 2025-11-07 12:11
![(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one — Beijing Ruidahenghui Technology Development Co., Ltd.](https://static.chemtradehub.com/suppliers/67cea2962b2de6e8e95a4940/67cea2962b2de6e8e95a4940-logo.webp){kind=logo}
![(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one — Shanghai Titan Shareholding Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cdfa4757537e5c8069b08b/67cdfa4757537e5c8069b08b-logo.webp){kind=logo}